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| Official symbol | HDAC6 |
| Gene id | 10013 |
| Organism | Homo sapiens |
| Official full symbol | histone deacetylase 6 |
| Gene type | protein-coding |
| Also known as | CPBHM, HD6, JM21, PPP1R90 |
| Summary | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. |
| Genomic regions | Chromosome X |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000334136.11 | HDAC6-201 | 4118 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 Q9UBN7 | NM_006044.4 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P2, TSL:1, |
| ENST00000443563.6 | HDAC6-210 | 4431 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 E7EP63 | - | GENCODE basic, APPRIS P2, TSL:4, |
| ENST00000376619.7 | HDAC6-203 | 4197 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 Q9UBN7 | - | GENCODE basic, APPRIS P2, TSL:1, |
| ENST00000423941.6 | HDAC6-205 | 4158 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 C9J172 | - | GENCODE basic, APPRIS P2, TSL:4, |
| ENST00000644068.1 | HDAC6-236 | 4147 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 Q9UBN7 | - | GENCODE basic, APPRIS P2, |
| ENST00000440653.2 | HDAC6-208 | 4145 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 E7ER52 | - | GENCODE basic, APPRIS P2, TSL:4, |
| ENST00000643374.2 | HDAC6-233 | 4110 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 Q9UBN7 | - | GENCODE basic, APPRIS P2, |
| ENST00000697349.1 | HDAC6-256 | 4108 | 1211aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000376610.7 | HDAC6-202 | 4107 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 A6NDI8 | - | GENCODE basic, APPRIS P2, TSL:5, |
| ENST00000376643.7 | HDAC6-204 | 4067 | 1215aa | Protein coding | CCDS14306 | A0A024QZ26 A6NDI8 | - | GENCODE basic, APPRIS P2, TSL:5, |
| ENST00000469223.6 | HDAC6-215 | 4061 | 1160aa | Protein coding | - | - | GENCODE basic, APPRIS ALT2, TSL:5, | |
| ENST00000643934.1 | HDAC6-235 | 3987 | 1160aa | Protein coding | A0A2R8YDE6 | - | GENCODE basic, APPRIS ALT2, | |
| ENST00000697320.1 | HDAC6-249 | 3985 | 1160aa | Protein coding | - | - | GENCODE basic, APPRIS ALT2, | |
| ENST00000697368.1 | HDAC6-257 | 3948 | 1166aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000642405.2 | HDAC6-232 | 3933 | 1192aa | Protein coding | A0A2R8Y559 | - | GENCODE basic, | |
| ENST00000697328.1 | HDAC6-251 | 3769 | 1108aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000477561.6 | HDAC6-219 | 3662 | 1160aa | Protein coding | - | - | GENCODE basic, APPRIS ALT2, TSL:5, | |
| ENST00000646703.2 | HDAC6-239 | 2771 | 893aa | Protein coding | A0A2R8YCS4 | - | GENCODE basic, | |
| ENST00000438518.6 | HDAC6-207 | 2172 | 146aa | Protein coding | CCDS87740 | C9JEF4 | - | GENCODE basic, TSL:4, |
| ENST00000462730.5 | HDAC6-212 | 1999 | 146aa | Protein coding | CCDS87740 | Q9BRX7 | - | GENCODE basic, TSL:1, |
| ENST00000697348.1 | HDAC6-255 | 1821 | 146aa | Protein coding | CCDS87740 | - | - | GENCODE basic, |
| ENST00000465269.6 | HDAC6-213 | 1152 | 146aa | Protein coding | CCDS87740 | Q9BRX7 | - | GENCODE basic, TSL:1, |
| ENST00000476625.5 | HDAC6-217 | 967 | 91aa | Protein coding | A0A2R8Y5Z4 | - | GENCODE basic, TSL:3, | |
| ENST00000461608.2 | HDAC6-211 | 954 | 211aa | Protein coding | A0A2R8Y758 | - | GENCODE basic, TSL:2, | |
| ENST00000441703.6 | HDAC6-209 | 591 | 146aa | Protein coding | CCDS87740 | Q9BRX7 | - | GENCODE basic, TSL:3, |
| ENST00000489352.5 | HDAC6-228 | 585 | 91aa | Protein coding | A0A2R8Y5Z4 | - | GENCODE basic, TSL:4, | |
| ENST00000647398.2 | HDAC6-240 | 3926 | 146aa | Nonsense mediated decay | CCDS87740 | A0A2R8YD35 | - | - |
| ENST00000697886.1 | HDAC6-274 | 3903 | 701aa | Nonsense mediated decay | - | - | - | |
| ENST00000498808.7 | HDAC6-231 | 3450 | 921aa | Nonsense mediated decay | - | - | TSL:5, | |
| ENST00000480525.6 | HDAC6-220 | 3305 | 669aa | Nonsense mediated decay | A0A2R8Y6Z9 | - | TSL:3, | |
| ENST00000488543.2 | HDAC6-226 | 5807 | No protein | Retained intron | - | - | TSL:2, | |
| ENST00000697347.1 | HDAC6-254 | 5794 | No protein | Retained intron | - | - | - | |
| ENST00000697893.1 | HDAC6-281 | 5373 | No protein | Retained intron | - | - | - | |
| ENST00000697417.2 | HDAC6-267 | 5336 | No protein | Retained intron | - | - | - | |
| ENST00000697389.1 | HDAC6-266 | 5266 | No protein | Retained intron | - | - | - | |
| ENST00000643659.1 | HDAC6-234 | 5249 | No protein | Retained intron | - | - | - | |
| ENST00000697852.1 | HDAC6-272 | 5151 | No protein | Retained intron | - | - | - | |
| ENST00000697385.1 | HDAC6-262 | 5089 | No protein | Retained intron | - | - | - | |
| ENST00000697370.1 | HDAC6-259 | 5079 | No protein | Retained intron | - | - | - | |
| ENST00000697373.1 | HDAC6-261 | 5060 | No protein | Retained intron | - | - | - | |
| ENST00000697889.1 | HDAC6-277 | 4949 | No protein | Retained intron | - | - | - | |
| ENST00000697388.1 | HDAC6-265 | 4941 | No protein | Retained intron | - | - | - | |
| ENST00000477528.5 | HDAC6-218 | 4832 | No protein | Retained intron | - | - | TSL:1, | |
| ENST00000697894.1 | HDAC6-282 | 4779 | No protein | Retained intron | - | - | - | |
| ENST00000486227.5 | HDAC6-224 | 4718 | No protein | Retained intron | - | - | TSL:2, | |
| ENST00000697281.1 | HDAC6-247 | 4717 | No protein | Retained intron | - | - | - | |
| ENST00000697552.1 | HDAC6-269 | 4673 | No protein | Retained intron | - | - | - | |
| ENST00000483656.6 | HDAC6-222 | 4608 | No protein | Retained intron | - | - | TSL:5, | |
| ENST00000697892.1 | HDAC6-280 | 4605 | No protein | Retained intron | - | - | - | |
| ENST00000697246.1 | HDAC6-241 | 4601 | No protein | Retained intron | - | - | - | |
| ENST00000697372.1 | HDAC6-260 | 4597 | No protein | Retained intron | - | - | - | |
| ENST00000697888.1 | HDAC6-276 | 4573 | No protein | Retained intron | - | - | - | |
| ENST00000697895.1 | HDAC6-283 | 4544 | No protein | Retained intron | - | - | - | |
| ENST00000697885.1 | HDAC6-273 | 4476 | No protein | Retained intron | - | - | - | |
| ENST00000644164.2 | HDAC6-237 | 4441 | No protein | Retained intron | - | - | - | |
| ENST00000697896.1 | HDAC6-284 | 4436 | No protein | Retained intron | - | - | - | |
| ENST00000697553.1 | HDAC6-270 | 4424 | No protein | Retained intron | - | - | - | |
| ENST00000645643.2 | HDAC6-238 | 4415 | No protein | Retained intron | - | - | - | |
| ENST00000697387.1 | HDAC6-264 | 4412 | No protein | Retained intron | - | - | - | |
| ENST00000697554.1 | HDAC6-271 | 4407 | No protein | Retained intron | - | - | - | |
| ENST00000697891.1 | HDAC6-279 | 4351 | No protein | Retained intron | - | - | - | |
| ENST00000697369.1 | HDAC6-258 | 4295 | No protein | Retained intron | - | - | - | |
| ENST00000697418.1 | HDAC6-268 | 4293 | No protein | Retained intron | - | - | - | |
| ENST00000697269.1 | HDAC6-246 | 4241 | No protein | Retained intron | - | - | - | |
| ENST00000697887.1 | HDAC6-275 | 4235 | No protein | Retained intron | - | - | - | |
| ENST00000697386.1 | HDAC6-263 | 4175 | No protein | Retained intron | - | - | - | |
| ENST00000697890.1 | HDAC6-278 | 4171 | No protein | Retained intron | - | - | - | |
| ENST00000486665.6 | HDAC6-225 | 4044 | No protein | Retained intron | - | - | TSL:2, | |
| ENST00000697319.1 | HDAC6-248 | 4043 | No protein | Retained intron | - | - | - | |
| ENST00000430858.2 | HDAC6-206 | 3802 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000495515.2 | HDAC6-230 | 3623 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000697345.1 | HDAC6-252 | 3195 | No protein | Retained intron | - | - | - | |
| ENST00000697346.1 | HDAC6-253 | 3186 | No protein | Retained intron | - | - | - | |
| ENST00000697267.1 | HDAC6-244 | 2748 | No protein | Retained intron | - | - | - | |
| ENST00000697247.1 | HDAC6-242 | 2647 | No protein | Retained intron | - | - | - | |
| ENST00000697266.1 | HDAC6-243 | 2541 | No protein | Retained intron | - | - | - | |
| ENST00000483506.2 | HDAC6-221 | 2376 | No protein | Retained intron | - | - | TSL:4, | |
| ENST00000697268.1 | HDAC6-245 | 2178 | No protein | Retained intron | - | - | - | |
| ENST00000697322.1 | HDAC6-250 | 1557 | No protein | Retained intron | - | - | - | |
| ENST00000489053.2 | HDAC6-227 | 903 | No protein | Retained intron | - | - | TSL:4, | |
| ENST00000470942.1 | HDAC6-216 | 668 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000485102.1 | HDAC6-223 | 667 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000468949.1 | HDAC6-214 | 572 | No protein | Retained intron | - | - | TSL:4, | |
| ENST00000493923.1 | HDAC6-229 | 404 | No protein | Retained intron | - | - | TSL:3, |
| Target Gene | HDAC6 |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene HDAC6 had been KO in hela cell line. |
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