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| Official symbol | ZBTB33 |
| Gene id | 10009 |
| Organism | Homo sapiens |
| Official full symbol | zinc finger and BTB domain containing 33 |
| Gene type | protein-coding |
| Also known as | ZNF-kaiso, ZNF348 |
| Summary | This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified. |
| Genomic regions | Chromosome X |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000557385.2 | ZBTB33-202 | 5253 | 672aa | Protein coding | CCDS14596 | Q86T24 | NM_001184742.2 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P1, TSL:1, |
| ENST00000326624.2 | ZBTB33-201 | 5211 | 672aa | Protein coding | CCDS14596 | Q86T24 | - | GENCODE basic, APPRIS P1, TSL:1, |
| Target Gene | ZBTB33 |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene ZBTB33 had been KO in hela cell line. |
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