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| Official symbol | TANK |
| Gene id | 10010 |
| Organism | Homo sapiens |
| Official full symbol | TRAF family member associated NFKB activator |
| Gene type | protein-coding |
| Also known as | I-TRAF, ITRAF, TRAF2 |
| Summary | The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Genomic regions | Chromosome 2 |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000392749.7 | TANK-202 | 2098 | 425aa | Protein coding | CCDS2215 | Q92844 | NM_001199135.3 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P1, TSL:1, |
| ENST00000405852.5 | TANK-205 | 2155 | 408aa | Protein coding | E7EQA9 | - | GENCODE basic, TSL:5, | |
| ENST00000259075.6 | TANK-201 | 2152 | 425aa | Protein coding | CCDS2215 | Q92844 | - | GENCODE basic, APPRIS P1, TSL:1, |
| ENST00000437623.1 | TANK-210 | 1702 | 275aa | Protein coding | H7C3L4 | - | TSL:5, CDS 5' incomplete, | |
| ENST00000402568.5 | TANK-203 | 878 | 239aa | Protein coding | E7EW82 | - | GENCODE basic, TSL:5, | |
| ENST00000406287.5 | TANK-206 | 875 | 238aa | Protein coding | E7EVA2 | - | GENCODE basic, TSL:5, | |
| ENST00000429217.5 | TANK-207 | 762 | 190aa | Protein coding | E7ENY2 | - | TSL:5, CDS 3' incomplete, | |
| ENST00000439442.1 | TANK-211 | 727 | 198aa | Protein coding | H7BZ28 | - | TSL:3, CDS 5' incomplete, | |
| ENST00000432002.5 | TANK-208 | 600 | 138aa | Protein coding | E7EV32 | - | TSL:5, CDS 3' incomplete, | |
| ENST00000456358.5 | TANK-214 | 564 | 165aa | Protein coding | E7EMT6 | - | TSL:5, CDS 3' incomplete, | |
| ENST00000403609.1 | TANK-204 | 555 | 119aa | Protein coding | CCDS46436 | Q92844-3 | - | GENCODE basic, TSL:1, |
| ENST00000440506.5 | TANK-212 | 550 | 105aa | Protein coding | E7EWR8 | - | TSL:3, CDS 3' incomplete, | |
| ENST00000457887.5 | TANK-215 | 762 | 128aa | Nonsense mediated decay | E7ERM9 | - | TSL:5, | |
| ENST00000432692.6 | TANK-209 | 576 | 125aa | Nonsense mediated decay | E7EM55 | - | TSL:5, | |
| ENST00000441987.5 | TANK-213 | 533 | 36aa | Nonsense mediated decay | E9PEK1 | - | TSL:5, | |
| ENST00000461338.5 | TANK-216 | 674 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000494976.1 | TANK-223 | 636 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000470324.1 | TANK-219 | 571 | No protein | Protein coding CDS not defined | - | - | TSL:4, | |
| ENST00000463502.1 | TANK-217 | 570 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000489393.1 | TANK-222 | 301 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000468831.5 | TANK-218 | 905 | No protein | Retained intron | - | - | TSL:1, | |
| ENST00000483622.1 | TANK-221 | 566 | No protein | Retained intron | - | - | TSL:5, | |
| ENST00000477952.1 | TANK-220 | 427 | No protein | Retained intron | - | - | TSL:2, |
| Target Gene | TANK |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene TANK had been KO in hela cell line. |
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