Official symbol | TANK |
Gene id | 10010 |
Organism | Homo sapiens |
Official full symbol | TRAF family member associated NFKB activator |
Gene type | protein-coding |
Also known as | I-TRAF, ITRAF, TRAF2 |
Summary | The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Genomic regions | Chromosome 2 |
Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ENST00000392749.7 | TANK-202 | 2098 | 425aa | Protein coding | CCDS2215 | Q92844 | NM_001199135.3 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P1, TSL:1, |
ENST00000405852.5 | TANK-205 | 2155 | 408aa | Protein coding | E7EQA9 | - | GENCODE basic, TSL:5, | |
ENST00000259075.6 | TANK-201 | 2152 | 425aa | Protein coding | CCDS2215 | Q92844 | - | GENCODE basic, APPRIS P1, TSL:1, |
ENST00000437623.1 | TANK-210 | 1702 | 275aa | Protein coding | H7C3L4 | - | TSL:5, CDS 5' incomplete, | |
ENST00000402568.5 | TANK-203 | 878 | 239aa | Protein coding | E7EW82 | - | GENCODE basic, TSL:5, | |
ENST00000406287.5 | TANK-206 | 875 | 238aa | Protein coding | E7EVA2 | - | GENCODE basic, TSL:5, | |
ENST00000429217.5 | TANK-207 | 762 | 190aa | Protein coding | E7ENY2 | - | TSL:5, CDS 3' incomplete, | |
ENST00000439442.1 | TANK-211 | 727 | 198aa | Protein coding | H7BZ28 | - | TSL:3, CDS 5' incomplete, | |
ENST00000432002.5 | TANK-208 | 600 | 138aa | Protein coding | E7EV32 | - | TSL:5, CDS 3' incomplete, | |
ENST00000456358.5 | TANK-214 | 564 | 165aa | Protein coding | E7EMT6 | - | TSL:5, CDS 3' incomplete, | |
ENST00000403609.1 | TANK-204 | 555 | 119aa | Protein coding | CCDS46436 | Q92844-3 | - | GENCODE basic, TSL:1, |
ENST00000440506.5 | TANK-212 | 550 | 105aa | Protein coding | E7EWR8 | - | TSL:3, CDS 3' incomplete, | |
ENST00000457887.5 | TANK-215 | 762 | 128aa | Nonsense mediated decay | E7ERM9 | - | TSL:5, | |
ENST00000432692.6 | TANK-209 | 576 | 125aa | Nonsense mediated decay | E7EM55 | - | TSL:5, | |
ENST00000441987.5 | TANK-213 | 533 | 36aa | Nonsense mediated decay | E9PEK1 | - | TSL:5, | |
ENST00000461338.5 | TANK-216 | 674 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
ENST00000494976.1 | TANK-223 | 636 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
ENST00000470324.1 | TANK-219 | 571 | No protein | Protein coding CDS not defined | - | - | TSL:4, | |
ENST00000463502.1 | TANK-217 | 570 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
ENST00000489393.1 | TANK-222 | 301 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
ENST00000468831.5 | TANK-218 | 905 | No protein | Retained intron | - | - | TSL:1, | |
ENST00000483622.1 | TANK-221 | 566 | No protein | Retained intron | - | - | TSL:5, | |
ENST00000477952.1 | TANK-220 | 427 | No protein | Retained intron | - | - | TSL:2, |
Target Gene | TANK |
This KO Strategy | loading |
Red Cotton™ Notes | Gene TANK had been KO in hela cell line. |
$80
Single gRNA plasmid off-shelf
$599
Single gRNA lentivirus
CRISPR-U™ technology is the exclusive gene-editing cell technology patent of Ubigene. With CRISPR-U™, Ubigene has successfully modified over 5000 genes from more than 200 mammalian cell lines including iPS/H1/H9 in the continuous upgrading process, and the KO efficiency 10~20-fold higher than conventional technology. Not only with higher cutting efficiency, but higher homologous recombination efficiency, CRISPR-U™ can achieve complete KO, point mutation and KI in cell lines. At present, Ubigene has successfully established a Cell Line Bank containing 3000+ off-shelf KO cells.
Chick here to get more infomation>Ubigene’s expert team has exclusively innovated and developed products, including cell lines, cell culture medium, kits, gRNA plasmids, off-shelf lentivirus, etc, which fully covers the experiment process of gene-editing in order to simplify the experiment process and improve the efficiency of gene-editing. Make genome editing easier!Currently hot-sales: Over 10,000 in-stock gRNA plasmids, >in-stock Cas9/Luc/EGFP Stable Cell Lines, Monoclone Validation Kit (extraction free), Cell Monoclonal Culture Medium, Transfection Culture Medium......
Chick here to get more infomation>Ubigene focuses on gene editing and has rich experience in cell line gene editing. Ubigene provides 8 major off-shelf libraries e.g. human/mouse genome-wide, as well as kinase-, cell cycle-, membrane protein-, and metabolic gene-related CRISPR knockout gRNA libraries, and one-stop services such as sgRNA library construction, virus packaging, cell transfection, antibiotic screening, NGS sequencing, and data analysis. Ubigene offers multiple deliverables to meet different research needs.
Chick here to get more infomation>Please leave your suggestion ×