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| Official symbol | ADA |
| Gene id | 100 |
| Organism | Homo sapiens |
| Official full symbol | adenosine deaminase |
| Gene type | protein-coding |
| Also known as | ADA1 |
| Summary | This gene encodes an enzyme that catalyzes the hydrolysis of adenosine to inosine in the purine catabolic pathway. Various mutations have been described for this gene and have been linked to human diseases related to impaired immune function such as severe combined immunodeficiency disease (SCID) which is the result of a deficiency in the ADA enzyme. In ADA-deficient individuals there is a marked depletion of T, B, and NK lymphocytes, and consequently, a lack of both humoral and cellular immunity. Conversely, elevated levels of this enzyme are associated with congenital hemolytic anemia. |
| Genomic regions | Chromosome 20 |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000372874.9 | ADA-201 | 1496 | 363aa | Protein coding | CCDS13335 | A0A0S2Z381 P00813 | NM_000022.4 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P2, TSL:1, |
| ENST00000537820.2 | ADA-207 | 2387 | 339aa | Protein coding | CCDS82618 | F5GWI4 | - | GENCODE basic, TSL:1, |
| ENST00000696076.1 | ADA-251 | 2032 | 441aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696017.1 | ADA-232 | 1927 | 417aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000536076.2 | ADA-205 | 1690 | 312aa | Protein coding | - | - | GENCODE basic, TSL:4, | |
| ENST00000696064.1 | ADA-245 | 1645 | 312aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000695927.1 | ADA-213 | 1630 | 389aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000695993.1 | ADA-219 | 1612 | 387aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696060.1 | ADA-241 | 1600 | 386aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696058.1 | ADA-239 | 1578 | 386aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696078.1 | ADA-253 | 1537 | 362aa | Protein coding | - | - | GENCODE basic, APPRIS ALT1, | |
| ENST00000696061.1 | ADA-242 | 1533 | 362aa | Protein coding | - | - | GENCODE basic, APPRIS ALT1, | |
| ENST00000696077.1 | ADA-252 | 1529 | 361aa | Protein coding | - | - | GENCODE basic, APPRIS ALT1, | |
| ENST00000696063.1 | ADA-244 | 1517 | 388aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696080.1 | ADA-255 | 1502 | 400aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696062.1 | ADA-243 | 1487 | 384aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696082.1 | ADA-257 | 1479 | 388aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696079.1 | ADA-254 | 1464 | 399aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000695949.1 | ADA-214 | 1450 | 338aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000696005.1 | ADA-226 | 1305 | 235aa | Protein coding | - | - | CDS 5' incomplete, | |
| ENST00000695995.1 | ADA-221 | 1085 | 233aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000695991.1 | ADA-217 | 1014 | 209aa | Protein coding | A0A0S2Z3B9 | - | GENCODE basic, | |
| ENST00000695889.1 | ADA-210 | 975 | 188aa | Protein coding | A0A0S2Z3T6 | - | GENCODE basic, | |
| ENST00000696065.1 | ADA-246 | 726 | 137aa | Protein coding | - | - | GENCODE basic, | |
| ENST00000695956.1 | ADA-215 | 572 | 125aa | Protein coding | - | - | CDS 5' incomplete, | |
| ENST00000696038.1 | ADA-237 | 1925 | 83aa | Nonsense mediated decay | - | - | - | |
| ENST00000696034.1 | ADA-233 | 1877 | 263aa | Nonsense mediated decay | - | - | - | |
| ENST00000695992.1 | ADA-218 | 1838 | 263aa | Nonsense mediated decay | - | - | - | |
| ENST00000696059.1 | ADA-240 | 1622 | 53aa | Nonsense mediated decay | - | - | - | |
| ENST00000696075.1 | ADA-250 | 1621 | 48aa | Nonsense mediated decay | - | - | - | |
| ENST00000536532.6 | ADA-206 | 1423 | 263aa | Nonsense mediated decay | F5GXW0 | - | TSL:5, | |
| ENST00000695994.1 | ADA-220 | 1383 | 254aa | Nonsense mediated decay | - | - | - | |
| ENST00000696006.1 | ADA-227 | 1362 | 239aa | Nonsense mediated decay | - | - | - | |
| ENST00000696007.1 | ADA-228 | 1301 | 119aa | Nonsense mediated decay | - | - | CDS 5' incomplete, | |
| ENST00000696104.1 | ADA-260 | 1180 | 204aa | Nonsense mediated decay | - | - | - | |
| ENST00000539235.6 | ADA-208 | 1096 | 75aa | Nonsense mediated decay | F5GYD4 | - | TSL:5, | |
| ENST00000695957.1 | ADA-216 | 1084 | 130aa | Nonsense mediated decay | - | - | - | |
| ENST00000696105.1 | ADA-261 | 848 | 178aa | Nonsense mediated decay | - | - | - | |
| ENST00000695891.1 | ADA-212 | 629 | 156aa | Nonsense mediated decay | - | - | - | |
| ENST00000695890.1 | ADA-211 | 5965 | No protein | Retained intron | - | - | - | |
| ENST00000696008.1 | ADA-229 | 4168 | No protein | Retained intron | - | - | - | |
| ENST00000696003.1 | ADA-224 | 4092 | No protein | Retained intron | - | - | - | |
| ENST00000696004.1 | ADA-225 | 3536 | No protein | Retained intron | - | - | - | |
| ENST00000696037.1 | ADA-236 | 3081 | No protein | Retained intron | - | - | - | |
| ENST00000696036.1 | ADA-235 | 2556 | No protein | Retained intron | - | - | - | |
| ENST00000696083.1 | ADA-258 | 2328 | No protein | Retained intron | - | - | - | |
| ENST00000696009.1 | ADA-230 | 2186 | No protein | Retained intron | - | - | - | |
| ENST00000696035.1 | ADA-234 | 2041 | No protein | Retained intron | - | - | - | |
| ENST00000696084.1 | ADA-259 | 1994 | No protein | Retained intron | - | - | - | |
| ENST00000696081.1 | ADA-256 | 1956 | No protein | Retained intron | - | - | - | |
| ENST00000696010.1 | ADA-231 | 1831 | No protein | Retained intron | - | - | - | |
| ENST00000464097.5 | ADA-202 | 1770 | No protein | Retained intron | - | - | TSL:2, | |
| ENST00000696073.1 | ADA-248 | 1715 | No protein | Retained intron | - | - | - | |
| ENST00000696039.1 | ADA-238 | 1684 | No protein | Retained intron | - | - | - | |
| ENST00000492931.6 | ADA-203 | 1569 | No protein | Retained intron | - | - | TSL:5, | |
| ENST00000695996.1 | ADA-222 | 1486 | No protein | Retained intron | - | - | - | |
| ENST00000696072.1 | ADA-247 | 1210 | No protein | Retained intron | - | - | - | |
| ENST00000695997.1 | ADA-223 | 1011 | No protein | Retained intron | - | - | - | |
| ENST00000696074.1 | ADA-249 | 955 | No protein | Retained intron | - | - | - | |
| ENST00000535573.1 | ADA-204 | 550 | No protein | Retained intron | - | - | TSL:5, | |
| ENST00000545776.5 | ADA-209 | 549 | No protein | Retained intron | - | - | TSL:5, |
| Target Gene | ADA |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene ADA had been KO in hela cell line. |
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