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| Official symbol | PDCD6IP |
| Gene id | 10015 |
| Organism | Homo sapiens |
| Official full symbol | programmed cell death 6 interacting protein |
| Gene type | protein-coding |
| Also known as | AIP1, ALIX, DRIP4, HP95 |
| Summary | This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. |
| Genomic regions | Chromosome 3 |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000307296.8 | PDCD6IP-201 | 5884 | 868aa | Protein coding | CCDS2660 | Q8WUM4 | NM_013374.6 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P2, TSL:1, |
| ENST00000457054.6 | PDCD6IP-206 | 5962 | 873aa | Protein coding | CCDS54561 | Q8WUM4-2 | - | GENCODE basic, APPRIS ALT1, TSL:1, |
| ENST00000413073.1 | PDCD6IP-203 | 566 | 153aa | Protein coding | C9IZF9 | - | TSL:4, CDS 3' incomplete, | |
| ENST00000648706.1 | PDCD6IP-218 | 6049 | 300aa | Nonsense mediated decay | A0A3B3IT07 | - | - | |
| ENST00000412887.5 | PDCD6IP-202 | 842 | 95aa | Nonsense mediated decay | F8WDK9 | - | TSL:3, | |
| ENST00000435909.5 | PDCD6IP-205 | 587 | 72aa | Nonsense mediated decay | F8WEQ7 | - | TSL:5, | |
| ENST00000430877.5 | PDCD6IP-204 | 582 | 78aa | Nonsense mediated decay | F8WBR8 | - | TSL:3, | |
| ENST00000498147.5 | PDCD6IP-217 | 802 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000482561.1 | PDCD6IP-211 | 626 | No protein | Protein coding CDS not defined | - | - | TSL:5, | |
| ENST00000484478.5 | PDCD6IP-212 | 596 | No protein | Protein coding CDS not defined | - | - | TSL:4, | |
| ENST00000477798.5 | PDCD6IP-210 | 587 | No protein | Protein coding CDS not defined | - | - | TSL:4, | |
| ENST00000495235.2 | PDCD6IP-216 | 428 | No protein | Protein coding CDS not defined | - | - | TSL:2, | |
| ENST00000465122.5 | PDCD6IP-208 | 894 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000489869.1 | PDCD6IP-214 | 842 | No protein | Retained intron | - | - | TSL:2, | |
| ENST00000487821.1 | PDCD6IP-213 | 750 | No protein | Retained intron | - | - | TSL:4, | |
| ENST00000459659.1 | PDCD6IP-207 | 662 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000494810.1 | PDCD6IP-215 | 619 | No protein | Retained intron | - | - | TSL:3, | |
| ENST00000473593.1 | PDCD6IP-209 | 540 | No protein | Retained intron | - | - | TSL:2, |
| Target Gene | PDCD6IP |
| This KO Strategy | loading |
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