Official symbol | HDAC5 |
Gene id | 10014 |
Organism | Homo sapiens |
Official full symbol | histone deacetylase 5 |
Gene type | protein-coding |
Also known as | HD5, NY-CO-9 |
Summary | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. |
Genomic regions | Chromosome 17 |
Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
ENST00000682912.1 | HDAC5-213 | 5319 | 1122aa | Protein coding | CCDS45696 | Q9UQL6 | NM_005474.5 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P4, |
ENST00000225983.10 | HDAC5-201 | 5326 | 1123aa | Protein coding | CCDS32663 | Q9UQL6-3 | - | GENCODE basic, APPRIS ALT2, TSL:5, |
ENST00000336057.9 | HDAC5-202 | 5040 | 1037aa | Protein coding | Q9UQL6-2 | - | GENCODE basic, TSL:1, | |
ENST00000586802.5 | HDAC5-204 | 3662 | 1122aa | Protein coding | CCDS45696 | Q9UQL6 | - | GENCODE basic, APPRIS P4, TSL:1, |
ENST00000588261.1 | HDAC5-207 | 846 | 282aa | Protein coding | K7EJL4 | - | TSL:3, CDS 5' and 3' incomplete, | |
ENST00000591714.5 | HDAC5-210 | 667 | 68aa | Protein coding | K7ES01 | - | TSL:3, CDS 3' incomplete, | |
ENST00000587135.1 | HDAC5-205 | 504 | 40aa | Protein coding | K7EJZ7 | - | TSL:2, CDS 3' incomplete, | |
ENST00000588703.5 | HDAC5-209 | 445 | 79aa | Protein coding | K7EJL6 | - | TSL:3, CDS 3' incomplete, | |
ENST00000592385.5 | HDAC5-211 | 2601 | No protein | Retained intron | - | - | TSL:5, | |
ENST00000593013.5 | HDAC5-212 | 1745 | No protein | Retained intron | - | - | TSL:2, | |
ENST00000587776.1 | HDAC5-206 | 917 | No protein | Retained intron | - | - | TSL:3, | |
ENST00000588419.1 | HDAC5-208 | 742 | No protein | Retained intron | - | - | TSL:2, | |
ENST00000586339.1 | HDAC5-203 | 465 | No protein | Retained intron | - | - | TSL:2, |
Target Gene | HDAC5 |
This KO Strategy | loading |
Red Cotton™ Notes | Gene HDAC5 had been KO in hela cell line. |
$80
Single gRNA plasmid off-shelf
$599
Single gRNA lentivirus
CRISPR-U™ technology is the exclusive gene-editing cell technology patent of Ubigene. With CRISPR-U™, Ubigene has successfully modified over 5000 genes from more than 200 mammalian cell lines including iPS/H1/H9 in the continuous upgrading process, and the KO efficiency 10~20-fold higher than conventional technology. Not only with higher cutting efficiency, but higher homologous recombination efficiency, CRISPR-U™ can achieve complete KO, point mutation and KI in cell lines. At present, Ubigene has successfully established a Cell Line Bank containing 3000+ off-shelf KO cells.
Chick here to get more infomation>Ubigene’s expert team has exclusively innovated and developed products, including cell lines, cell culture medium, kits, gRNA plasmids, off-shelf lentivirus, etc, which fully covers the experiment process of gene-editing in order to simplify the experiment process and improve the efficiency of gene-editing. Make genome editing easier!Currently hot-sales: Over 10,000 in-stock gRNA plasmids, >in-stock Cas9/Luc/EGFP Stable Cell Lines, Monoclone Validation Kit (extraction free), Cell Monoclonal Culture Medium, Transfection Culture Medium......
Chick here to get more infomation>Ubigene focuses on gene editing and has rich experience in cell line gene editing. Ubigene provides 8 major off-shelf libraries e.g. human/mouse genome-wide, as well as kinase-, cell cycle-, membrane protein-, and metabolic gene-related CRISPR knockout gRNA libraries, and one-stop services such as sgRNA library construction, virus packaging, cell transfection, antibiotic screening, NGS sequencing, and data analysis. Ubigene offers multiple deliverables to meet different research needs.
Chick here to get more infomation>Please leave your suggestion ×