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| Official symbol | AKT3 |
| Gene id | 10000 |
| Organism | Homo sapiens |
| Official full symbol | AKT serine/threonine kinase 3 |
| Gene type | protein-coding |
| Also known as | MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2 |
| Summary | The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. |
| Genomic regions | Chromosome 1 |
| Transcript ID | Name | bp | Protein | Biotype | CCDS | UniProt Match | RefSeq Match | Flags |
| ENST00000673466.1 | AKT3-217 | 7281 | 479aa | Protein coding | CCDS31077 | Q9Y243 | NM_005465.7 | MANE Select, Ensembl Canonical, GENCODE basic, APPRIS P1, |
| ENST00000366539.6 | AKT3-203 | 4967 | 456aa | Protein coding | A0A5K1VW74 | - | GENCODE basic, TSL:5, | |
| ENST00000672578.1 | AKT3-214 | 4925 | 418aa | Protein coding | A0A5F9ZHU3 | - | GENCODE basic, | |
| ENST00000672238.1 | AKT3-211 | 3417 | 100aa | Protein coding | A0A7P0TB29 | - | GENCODE basic, | |
| ENST00000492957.2 | AKT3-208 | 3225 | 247aa | Protein coding | A0A7P0TBJ6 | - | GENCODE basic, TSL:5, | |
| ENST00000336199.9 | AKT3-202 | 1688 | 465aa | Protein coding | CCDS31076 | Q9Y243-2 | - | GENCODE basic, TSL:1, |
| ENST00000263826.12 | AKT3-201 | 1583 | 479aa | Protein coding | CCDS31077 | Q9Y243 | - | GENCODE basic, APPRIS P1, TSL:1, |
| ENST00000366540.5 | AKT3-204 | 1575 | 465aa | Protein coding | CCDS31076 | Q9Y243-2 | - | GENCODE basic, TSL:1, |
| ENST00000680056.1 | AKT3-219 | 1314 | 437aa | Protein coding | A0A7P0T8T9 | - | GENCODE basic, | |
| ENST00000491219.6 | AKT3-207 | 602 | 71aa | Protein coding | A0A5F9ZGZ4 | - | TSL:3, CDS 5' incomplete, | |
| ENST00000673400.1 | AKT3-216 | 427 | 66aa | Protein coding | A0A7P0T872 | - | GENCODE basic, | |
| ENST00000672442.1 | AKT3-212 | 3415 | 94aa | Nonsense mediated decay | A0A5F9ZHA9 | - | - | |
| ENST00000680118.1 | AKT3-220 | 2374 | 479aa | Nonsense mediated decay | CCDS31077 | Q9Y243 | - | - |
| ENST00000672460.1 | AKT3-213 | 2072 | 398aa | Nonsense mediated decay | A0A5F9ZGY0 | - | CDS 5' incomplete, | |
| ENST00000681794.1 | AKT3-222 | 1543 | 295aa | Nonsense mediated decay | A0A7P0TB32 | - | - | |
| ENST00000490018.1 | AKT3-206 | 664 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000672679.1 | AKT3-215 | 589 | No protein | Protein coding CDS not defined | - | - | - | |
| ENST00000550388.1 | AKT3-209 | 572 | No protein | Protein coding CDS not defined | - | - | TSL:4, | |
| ENST00000463991.5 | AKT3-205 | 422 | No protein | Protein coding CDS not defined | - | - | TSL:3, | |
| ENST00000679831.1 | AKT3-218 | 7950 | No protein | Retained intron | - | - | - | |
| ENST00000681055.1 | AKT3-221 | 5343 | No protein | Retained intron | - | - | - | |
| ENST00000552631.2 | AKT3-210 | 557 | No protein | Retained intron | - | - | TSL:4, |
| Target Gene | AKT3 |
| This KO Strategy | loading |
| Red Cotton™ Notes | Gene AKT3 had been KO in hela cell line. |
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